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Increases in bone turnover have already been reported within the perimenopausal period in humans almost certainly resulting from estrogen deficiency.

The pharmacokinetics studies of these active components of SM in animals showed that they are absorbed orally and randomized clinical trials BI-1356 and clinical experiences indicate that the SM products are safe with a low side effect profile. Therefore, SM is a promising osteoporosis therapeutic agent candidate, although the specific mechanism of the anti osteoporotic effect of SM needs to be clarified. Currently eight small molecule kinase inhibitor drugs and a handful of protein/antibody therapeutics targeting kinases have been approved for human use. A large number of kinase inhibitor discovery programs have been focused on drugs for the treatment of inflammation and autoimmune disorders, however, the approved drugs to date have been useful for the treatment of a variety of cancers in humans.

This review will cover the recent publications, primarily from 2006?2007, describing inhibitors of IKK2, Syk, Lck, and JAK3. Inhibitors of kinases such as BTK and Fyn are not covered in this review. Some of the publications cited in this BI-1356"href="http://www.selleckchem.com/products/linagliptin-bi-1356.html">BI-1356 review refer to the inhibitors reported earlier for that kinase. A large number of patents on kinase inhibitors describe, sometimes with very little, if any, information on the biological profile of compounds. This chapter will not cover such disclosures. Additionally, a majority of kinase inhibitors disclosed as having inhibitory activity for one kinase are found to be potent inhibitors of other kinases. This review will focus on the kinase inhibitors that are profiled for a particular kinase with potential application in inflammation.

Based on the critical role of NF ?B in the immune system and on the data from knockout mice, it has been postulated that chronic inhibition of this transcription factor could lead to opportunistic infections and hepatic toxicity.