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A specic Brutons tyrosine kinase inhibitor, histone deacetylase inhibitor was also tested as a treatment for GVHD, treated mice showed increased survival rates and had less clinical GVHD. The combined treatment of LFM A13 with JANEX 3 was more effective than treatment with LFM A13 or JANEX 3 alone. Taken together, these results indicate that signaling molecules downstream of chemokine signaling may be useful targets for treating GVHD. In the context of the treatment of hematological malignances, such as leukemia, engraftment of donor cells is important to restore the immune system after ablative therapy. In addition to reconstructing the immune system, the engrafted cells are thought to contribute to chemotherapy by inducing an anti tumor effect, an effect that is known as. Several therapies

of such molecules include chemokine receptor IEM 1754 antagonists, modied chemokines that act as antagonist molecules, neutralizing antibodies to the chemokines or their receptors and chemokine binding proteins. In 2007, the FDA approved maraviroc, an inhibitor of CCR5 for the prevention of HIV infection, which was the rst triumph for a small molecule drug acting on the chemokine system. A second small molecule drug, a CXCR4 antagonist for haematopoietic stem cell mobilization, was approved by the FDA at the end of 2008. The results of a Phase III trial with a CCR9 inhibitor for Crohns disease are also promising. The latter drug could represent the rst success for a chemokine receptor antagonist to be used as an anti inammatory therapeutic. Development

and bacterial translocation and sepsis are important causes of death in GVHD patients. Finally, young mice are usually used in experimental GVHD induction, but GVHD is generally more common in older people. These differences should not hamper development of drugs against GVHD but do not need to be taken into consideration when moving drugs forward into clinical trials. Fewer studies have been performed to validate the use of inhibitors of the chemokine system in experimental GVHD. In PARP this context,